Stems Cells and Immunity

Since the early days of modern medicine it has been known that transplantation of tissues from one individual to other results in immune rejection, except when performed between identical twins. Extensive research done in the past decades has uncovered that differences in protein sequences between individuals are the primary targets for the immune response against allogeneic (genetically non-identical) grafts. These molecules were subsequently defined as histocompatibility antigens as they determine whether implanted cells are accepted or rejected by the immune system. Today, the risk of organ rejection remains high despite efforts to match haplotypes of histocompatibility antigens as well as use of immunosuppressive therapies.

Human embryonic stem cells (hESCs) can be propagated in high numbers in vitro, and have the potential to differentiate into a myriad of cell the application of these cells for organ restoration is of particular importance due to limited availability of donated organs. However, it is unclear whether differentiated hESCs will be recognized by the immune system following implantation in humans. Therefore it is imperative to investigate the immune response against differentiated hESCs for successful clinical translation.

The purpose of this review is to describe the current knowledge of antigenicity and immunogenicity of hESCs and their derivatives. While antigenicity refers only to the capacity of cells to express histocompatibility antigens, immunogenicity is a broader term for the potential to elicit immune response through additional factors, such as co-stimulatory molecules. This review summarizes our current view of the histocompatibility antigens and immunomodulating molecules that are expressed on undifferentiated and differentiated hESCs (u/dhESCs). In addition, adaptive and innate immune processes that may develop against the cells following recognition of histocompatibility antigens will be discussed. As rejection processes could severely limit the use of hESC-derived transplants, multiple approaches are being developed to alleviate these risks. I will focus on techniques for derivation of isogenic (genetically identical) hESC lines and discuss the immunological benefits and remaining challenges for their potential application.

·               Expression of histocompatibility antigens on u/dhESCs

·               Expression of T-cell regulating signals in u/dhESCs

·               T-cell response against u/dhESCs measured by functional assays

·               Generation of patient-specific isogenic hESC lines

·               Evidence that malignant progenitor cells

·               Donor natural killer (NK) cells as mediators

·               Antigen processing and presentation

·               Nucleic Acid Sensing Pathways

  • Donor Natural Killer (NK) Cells
  • Immunogenecity

Related Conference of Stems Cells and Immunity

May 08-10, 2017

10th Asia-Pacific Pharma Congress

Singapore
May 15-16, 2017

7th European Biosimilars Congress

Munich, Germany
May 22-23, 2017

6th World Pharmacists & Clinical Pharmacy Annual Congress

(10 Plenary Forums - 1 Event)
Chicago, Illinois, USA
July 06-08, 2017

8th Global Pharmacovigilance & Drug Safety Summit

Kuala Lumpur, Malaysia
June 19-21, 2017

4th World Congress on Mass Spectrometry

London, UK
June 26-28, 2017

9th Annual European Pharma Congress

Madrid, Spain
July 17-18, 2017

9th World Congress on BA/BE Studies and Biowaivers

Melbourne, Australia
July 24-26, 2017

8th World Congress on Pharmacology and Toxicology

Melbourne, Australia
July 31-Aug 02, 2017

7th Global Experts Meeting on Neuropharmacology

Milan, Italy
July 31-Aug 01, 2017

Global Experts Meeting on Pharmaceutics & Drug Delivery Systems

Melbourne, Australia
August 02-03, 2017

Analytical and Bio-Analytical Techniques Congress

Melbourne, Australia
August 07-09, 2017

4th World Congress on Chromatography

Rome, Italy
August 31-September 01, 2017,

3rd International Conference on Biopharmaceutics and Biologic Drugs

Philadelphia, USA
(10 Plenary Forums - 1Event)
August 31-September 01, 2017

5th International Pharmacy Conference


(10 Plenary Forums - 1 Event)
Las Vegas, Nevada, USA
September 04-06, 2017

9th World Congress on Pharmacology

Paris, France
September 11-13, 2017

4th International Conference on Clinical Trials

San Antonio, Texas, USA
(10 Plenary Forums - 1 Event)
September 11-13, 2017

World Congress on Biotherapeutics and Bioanalytical Techniques

(10 Plenary Forums - 1Event) Dallas, Texas, USA
September 18-20, 2017

6th International Conference on Forensic Research & Technology

(10 Plenary Forums - 1Event)
Houston, Texas, USA
Sep 25-27, 2017

12th Annual
Pharma Middle East Congress

Dubai, UAE
October 02-03, 2017

9th Annual Pharmaceutical Analysis Congress

Vienna, Austria
October 09-11, 2017

Global Experts Meeting on Case Reports

Osaka, Japan
Oct 12-13, 2017

Annual Meeting on Pharmacology

Melbourne, Australia
October 12-14, 2017

Global Experts Meeting on Clinical Pharmacy

Auckland, Newzeland
October 16-17, 2017

16th Annual Medicinal & Pharmaceutical Sciences Congress

Seoul, South Korea
October 16-18, 2017
(10 Plenary Forums - 1 Event)

4th International Conference on Past and Present Research Systems of Green Chemistry

Atlanta, Georgia, USA
October 18-19, 2017

6th Global Congress on Mass Spectrometry

Osaka, Japan
October 19-20, 2017

9th Annual Congress on Drug Design & Drug Formulation

Seoul, South Korea
October 19-20, 2017

4th International Conference and Exhibition on Pain Medicine

(10 Plenary Forums - 1 Event)
San Francisco, California, USA
(10 Plenary Forums - 1 Event) October 23-24, 2017

5th International Conference on Clinical and Hospital Pharmacy

Orlando, Florida, USA
December 07-09, 2017

International Conference on Biotech Pharmaceuticals

Paris, France
October 30-November 01, 2017
A B2B Networking & Global Knowledge Exchange Forum

Global Summit on Emerging Orphan Drugs and  Rare Diseases

San Antonio, Texas, USA
November 13-14, 2017

Global Experts Meeting on Toxicology

Singapore
Nov 16-18, 2017

International Meeting on Nutraceuticals

Dubai, UAE

Stems Cells and Immunity Conference Speakers

Recommended Sessions

Related Journals

Are you interested in